Palmitoyl Tetrapeptide-20 for Grey Hair Serum
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Mechanism of Action:
Palmitoyl Tetrapeptide-20 may stimulate melanogenesis or protect melanocytes. Preliminary studies suggest it enhances pigment production (verify with recent research).
Stability:
Maintain pH 5.5–6.5 (skin-friendly and peptide-stable).
Avoid high temperatures (>40°C), UV exposure, and harsh solvents.
Delivery System:
Use liposomes or nanoemulsions to enhance scalp penetration.
Consider water-based serum for follicle accessibility.
Palmitoyl Tetrapeptide-20 use Concentration:
Recommended: 0.01%–0.1% (confirm with supplier data).
Formula Composition (INCI Names)
| Phase | Ingredient | Function | % Range |
|---|---|---|---|
| Water | Deionized Water | Solvent | q.s. to 100 |
| Humectant | Glycerin | Moisturizer/Penetration aid | 3–5% |
| Active | Palmitoyl Tetrapeptide-20 | Melanocyte stimulation | 0.01–0.1% |
| Solvent | Propanediol | Stabilizer/Solubilizer | 2–4% |
| Antioxidant | Tocopherol (Vitamin E) | Stabilizer | 0.1–0.5% |
| Soothing | Bisabolol | Anti-irritant | 0.1–0.3% |
| Preservative | Phenoxyethanol (and) Ethylhexylglycerin | Preservative | 0.5–1% |
| pH Adjuster | Citric Acid/Sodium Citrate | pH Adjustment | As needed |
Palmitoyl Tetrapeptide-20 Manufacturing Process
Water Phase:
Heat deionized water to 25–30°C.
Dissolve glycerin and propanediol with gentle stirring.
Active Incorporation:
Slowly add Palmitoyl Tetrapeptide-20 under low shear mixing to avoid foaming.
Incorporate liposomal carrier if used.
pH Adjustment:
Adjust to pH 5.5–6.5 using citric acid/sodium citrate.
Additions:
Mix in tocopherol and bisabolol.
Add preservative last, ensuring even distribution.
Cooling & Packaging:
Cool to room temperature.
Package in opaque, airless pump bottles to prevent oxidation.
Palmitoyl Tetrapeptide-20 Efficacy & Safety Testing
Stability Tests: Accelerated aging (3 months at 25°C/60% RH) to check peptide integrity.
Patch Test: Ensure non-irritation on 50 volunteers.
Clinical Trials: Measure melanin density in hair follicles over 3–6 months.
Palmitoyl Tetrapeptide-20 Application Guidelines
Usage: Apply 1–2 mL daily to clean scalp, massaging gently.
Synergies: Combine with antioxidants (e.g., Vitamin C) or scalp health boosters (niacinamide).
Palmitoyl Tetrapeptide-20 Regulatory & Marketing
Compliance: Ensure adherence to EU/US cosmetic regulations (e.g., no drug claims).
Claims: Focus on "supports natural hair color" or "reduces premature greying."
Keywords: Mobelbiochem, Palmitoyl Tetrapeptide-20 price
