Chemical modification:
Introduce lipophilic groups onto the PDRN molecules, turning the originally hydrophilic molecular surface into a lipophilic one, so it can naturally blend into the oil phase.
Encapsulation delivery:
Wrap PDRN in liposomes, nanospheres, or oil-soluble carriers to form particles that can stably disperse in the oil phase, then release through skin lipid channels.
Structural transformation and combination:
By using molecular weight grading, dual molecular weight fragment design, etc., different-sized PDRN fragments become more stable in the oil phase while balancing rapid penetration and sustained release.
