Nonapeptide-1

Product Name: Nonapeptide-1
INCI Name: Nonapeptide-1
Reference: Melanostatine-5, Melanostatine,Melitane
Cas No: 158563-45-2
Sequence: Met-Pro-{D-Phe}-Arg-{D-Trp}-Phe-Lys-Pro-Val-NH2
Purity(hplc): 98.0% Min
Grade: Cosmetic Grade

Nonapeptide 1 structure

Quality: See COA,HPLC,MS reparts attached
Appearance: White Powder
Shelf life: 24 months
Packing: In bottle ,Foil bag or according to requested
Min order： 1 Grams

Descriptions:
Nonapeptide-1, is a propriety peptide that was originally developed for its antimicrobial activities. Animal research has revealed, however, that nonapeptide-1 can inhibit the synthesis of melanin, which makes it of interest for treating certain skin conditions. Animal models suggest that nonapeptide-1 can reduce synthesis of melanin and help decrease skin pigmentation to a substantial degree.
Nonapeptide 1 is of primary research interest for its ability to reduce hyperpigmentation by inhibiting the action of tyrosinase in melanin-producing cells.
The ability to regulate melanin production has potential application in a number of conditions, including photodamage of the skin.
Research also suggests that Melitane may play a role in the central nervous system where it may act on both dopaminergic receptors
and opioid receptors to modify pain signaling as well as behavior. Studies in mice support the idea that nonapeptide-1 may have central actions that affect behavior and pain.

Nonapeptide-1 mechanism of action:
Nonapeptide-1 is a biomimetic peptide, which has a very good match with MC1 receptors on melanocytes, so it can be used as a counteragent of melanocytes hormone,
competitively binding to MC1 receptors, preventing tyrosinase from being further activated to produce melanin, inhibiting melanin production, and brightening skin tone.

Nonapeptide 1 Benefits for skin
Inhibits melanin formation and whitening
Brightens skin tone and lightens dark spots
Whitening, brightening, freckle removal

 Nonapeptide-1 Clinically tested
100 Asian women between the ages of 18-45, including all types of skin, were selected as volunteers for the study. Volunteers were given a whitening nonapeptide emulsion.on one side of their face and an ineffective control emulsion on the other, which was applied twice a day for two months. 79% of people believe that the whitening ability of whitening nonapeptide is obvious.

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