Description
Product Name: Ac-Devd-Cho
Sequence：N-Acetyl-Asp-Glu-Val-Asp-al
CAS No.:169332-60-9
Molecular Weight:502.47
Formula ：C20H30N4O11
Ac-Devd-Cho structure
NMR: Consistent with HPLC
Physical and chemical properties
Purity: 95.0% Min
Appearance: White power
Package size: 100mg-1.0g bottle
Storage
(From the date of receipt):3 years -20°C powder
Descriptions
Ac-Devd-Cho is a synthetic tetrapeptide competitive inhibitor for Caspase-3/7, and contains the amino acid sequence of the PARP cleavage site. Ac-DEVD-CHO can be used to inhibit Caspase-3/7 activity in apoptotic cells, and to study events downstream of Caspase-3/7 activation.
Ac-DEVD-CHO is a synthetic peptide aldehyde with the PARP cleavage site DEVD, which is recognized by caspases (Nicholson et al.). Ac-DEVD-CHO blocks PARP cleavage activity and inhibits caspase-3 (Ki = 0.23 nM) and caspase-7 (Ki = 1.6 nM) in a reversible manner (Garcia-Calvo et al.; Talanian et al.). This inhibition is via the aldehyde group’s interaction with the active site cysteine of these caspases (Thornberry et al.). Caspase inhibitors are used to investigate caspase activation and apoptosis. This product is supplied as the trifluoroacetate salt of the molecule.
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