Tiger17
Tiger17 is an 11 amino acid peptide with a disulphide bridge between cysteines 2 and 10, which is a potent healer of skin wounds.
Description
Product name: : Tiger17
Synonyms: H-Trp-Cys-Lys-Pro-Lys-Pro-Lys-Pro-Arg-Cys-His-NH2
Molecular Weight： 1377.69
Formula ： C62H97N21O11S2 • XCF3COOH
Sequence： WCKPKPKPRCH-NH2
Purity >95% by HPLC
Modifications： Contains a disulphide bridge between cysteines 2 and 10
Solubility： Soluble in DMSO as stock and physiological buffers
Appearance: White powder
Storage Store desiccated, frozen and in the dark
Activity:Potent healer of skin wounds
Tiger17 is an 11 amino acid peptide with a disulphide bridge between cysteines 2 and 10, which is a potent healer of skin wounds. Tiger17 was designed based on the antimicrobial peptides tigerinin-RC1 and tigerinin RC2, identified from the skin secretions of the crab eating frog Fejervarya cancrivora which also exert wound healing activity. Tiger17 exerts significant effects at various stages of wound healing progresses - the induction of macrophage recruitment to the wound site at the inflammatory reaction stage, the promotion of migration and proliferation of keratinocytes and fibroblasts, and at the tissue remodeling phase. In mouse models Tiger17 accelerates the healing of full-thickness wounds and promotes re-epithelialization of skin wounds.
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