KPV Peptide

Product name: KPV peptide
Synonyms: H-LYS-PRO-VAL-OH ACETATE SALT; H-LYS-PRO-VAL-OH ACOH; ALPHA-MSH (11-13); ALPHA-MSH (11-13) ACETATE SALT; msh(11-13; .alpha.-MSH (11-13) (free acid); H-Lys-Pro-Val-OH; alpha-Msh (11-13) (free acid) acetate salt
UPAC Condensed: H-Lys-Pro-Val-OH
Sequence: KPV
CAS No: 67727-97-3
Molecular Formula: C16H30N4O4
Molecular Weight: 342.44
Purity (HPLC) ≥98.0%
Shelf life: > 2 years
Appearance: White or Off-white Lyophilized Powder

Package size: 1g,10g,50g,100g

What is KPV peptide?
KPV (lysine-proline-valine) is the C-terminal end of a more prominent melanocortin peptide hormone called alpha-melanocyte-stimulating hormone (α-MSH), produced naturally in the body. A melanocortin receptor agonist, α-MSH, is synthesized in the pituitary gland of most vertebrates and is responsible for regulating energy balance. Alpha-MSH and derivatives like Melanotan 2 are used in various contexts, including sunless tanning, sexual disorders, and sleep enhancement. Studies have also demonstrated α-MSH's immunomodulating and anti-inflammatory effects. KPV peptide's anti-inflammatory effects are particularly notable because it directly influences processes inside the cell. The small molecular size of KPV and α‐MSH allows them to enter the cell and interact with inflammatory signalling molecules. Specifically, they regulate inflammatory responses such as NF-κB activation, the proliferation of T-cells, expression of adhesion molecules, inflammatory cytokines, chemokine receptors, and inflammatory cell migration.

Researchers have proposed KPV and α-MSH as suitable treatments for inflammatory skin and bowel disease, fibrosis, allergic and inflammatory pulmonary disease, inflammation of the eyes, and arthritis.

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